Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis

نویسندگان

  • Georg F. Weber
  • Benjamin G. Chousterman
  • Ingo Hilgendorf
  • Clinton S. Robbins
  • Igor Theurl
  • Louisa M.S. Gerhardt
  • Yoshiko Iwamoto
  • Tam D. Quach
  • Muhammad Ali
  • John W. Chen
  • Thomas L. Rothstein
  • Matthias Nahrendorf
  • Ralph Weissleder
  • Filip K. Swirski
چکیده

Pneumonia is a major cause of mortality worldwide and a serious problem in critical care medicine, but the immunophysiological processes that confer either protection or morbidity are not completely understood. We show that in response to lung infection, B1a B cells migrate from the pleural space to the lung parenchyma to secrete polyreactive emergency immunoglobulin M (IgM). The process requires innate response activator (IRA) B cells, a transitional B1a-derived inflammatory subset which controls IgM production via autocrine granulocyte/macrophage colony-stimulating factor (GM-CSF) signaling. The strategic location of these cells, coupled with the capacity to produce GM-CSF-dependent IgM, ensures effective early frontline defense against bacteria invading the lungs. The study describes a previously unrecognized GM-CSF-IgM axis and positions IRA B cells as orchestrators of protective IgM immunity.

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عنوان ژورنال:

دوره 211  شماره 

صفحات  -

تاریخ انتشار 2014